Taming reactive radicals to streamline C-glycoside drug synthesis

This article was originally posted on Chemical Engineering Online.

Summary

Scripps Research reports a simplified, protecting‑group‑free route to make metabolically stable, acid‑resistant C‑glycosides directly from common sugars. By taming reactive radicals to forge key carbon–carbon bonds without hazardous reagents, the method avoids laborious hydroxyl protection/deprotection steps, promising broader substrate compatibility, higher step economy, and faster synthesis for C‑glycoside drug candidates.

What drug classes or applications do you think could benefit most from this protecting‑group‑free, radical C‑glycoside synthesis, and what hurdles might remain for industrial scale‑up?

Many widely used pharmaceuticals depend on a carbohydrate class known as C-glycosides, which are metabolically stable and acid-resistant. Although they can be made from common sugars like dextrose, C-glycosides have proven difficult to synthesize due to the preponderance of hydroxyl groups that act as hurdles to forging new carbon-carbon bonds. A research team at Scripps Researchhas demonstrated a simplified C-glycoside synthesis pathway that eliminates hazardous reagents and overcomes the need to “shield” and “unshield” hydroxyls during the formation of key chemical bonds.

The post Taming reactive radicals to streamline C-glycoside drug synthesis appeared first on Chemical Engineering.

Taming reactive radicals to streamline C-glycoside drug synthesis

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