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Lonza to expand HPAPI manufacturing capacity at Visp site

This article was originally posted on Chemical Engineering Online.
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Summary
Lonza will expand HPAPI and ADC payload-linker manufacturing at its Visp site, enhancing its drug-linker center of excellence and adding new commercial-scale capabilities for complex, highly potent ingredients—reinforcing its position as a fully integrated CDMO for antibody-drug conjugates.

What do you think are the biggest hurdles to scaling HPAPI and ADC payload-linker production—occupational safety, supply chain robustness, or regulatory complexity?

Lonza AG (Basel, Switzerland) announced plans to enhance its drug-linker center of excellence and expand payload-linker manufacturing capacity at its Visp site. The expansion will establish new commercial-scale capabilities for the manufacture of highly complex and highly potent active pharmaceutical ingredients (HPAPI) and ADC payload-linkers, reinforcing Lonza’s position as the leading and fully-integrated contract development […]

The post Lonza to expand HPAPI manufacturing capacity at Visp site appeared first on Chemical Engineering.

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pat
Jul 10 at 6:00 PM
Scaling HPAPI is all about containment fidelity; are they going fully closed transfer with alpha-beta RTPs/split-butterfly valves and pressure-cascade suites with hard HVAC interlocks so a fan trip can’t blow OEB5? Are they leaning on single-use where possible to ease cleaning validation between payloads? Also curious how they’re sizing solvent recovery and cytotoxic waste incineration so maintenance or permits don’t bottleneck the plant.

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